The role of visceral obesity and insulin resistance in right ventricular function in patients with metabolic syndrome

Abstract Background Evidence shows a strong relationship between visceral obesity, insulin resistance, metabolic syndrome (MetS) and cardiovascular disease risk. The role of right ventricular (RV) function is indisputably important in estimating patient's prognosis. Multiple studies demonstrate that fat represents metabolically active organ, secreting plethora vasoactive substances may have impact on cardiometabolic risk profile the patient, especially under circumstances MetS. Purpose objective our study was to evaluate obesity resistance RV patients with Methods included 100 subjects MetS (mean age 53±8.9 years) controls without 51±9.3 years, P=0.08). defined by ≥3 criteria IDF, AHA/NHLBI. participants underwent complete 2D echocardiography abdominal sonography assessment diastolic RV: ratio early late tricuspid flow velocities (Et/At), velocity annular (Et/e't), Et deceleration time (DT); systolic function: TAPSE, ejection fraction (EF); global Tei index (by pulsed tissue Doppler); sonographic parameters: epicardial thickness (EFT), intra-abdominal (IFT), wall (AWFI). status determined HOMA-IR≥2.5. Results All parameters function, as well index, were significantly changed group (P<0.05 for all parameters). Systolic showed no statically differences among groups (TAPSE 20,4±1,7 mm vs. 21.4±2.3 mm, P=0.087; EF 53±3% 54±4%, P=0.092). In we found correlations (Et/At, Et/e'T, EtDT) EFT (respectively: r=−0.524, P<0.001; r=0.291, r=0.692, P<0.001), IFT r=−0.342, r=0.335, r=0.592, AWFI r=−0.426, r=0.212, P=0.002; r=0.538, P<0.001). (determined Doppler) (r=0.623, r=0.618, (r=0.498, r=0.530, P<0.001) (r=0.313, P=0.001; r=0.307, P=0.001). HOMA-IR ≥2.5 dysfunction 5 times higher. did not show selected obesity. Multivariate regression analysis independently associated (P<0.05). Conclusions Our findings support (especially EFT) are Funding Acknowledgement Type funding sources: None.